Development of new methods for metabolite identification

MS-based untargeted proteomics and metabolomics

Development of new MS data analysis methods

 

12/2015-03/2019 Postdoctoral Fellow in European Molecular Biology Laboratory (EMBL), Germany

09/2008-06/2014 Ph.D. in Biochemistry and Molecular Biology, Xiamen University, China

09/2004-07/2008 B.Sc. in Life Science, Xiamen University, Xiamen, China

 

9.  Li Y., Kuhn M, Gavin A-C, Bork P. (2019) Identification of metabolites from tandem mass spectra with a machine learning approach utilizing structural features. Bioinformatics.

8.  Kastritis PL, O’Reilly FJ, Bock T, Li Y., Rogon MZ, Buczak K, Romanov N, Betts MJ, Bui KH, Hagen WJ, Hennrich ML, Mackmull M-T, Rappsilber J, Russell RB, Bork P, Beck M, Gavin A-C. (2017) Capturing protein communities by structural proteomics in a thermophilic eukaryote. Mol Syst Biol 13(7):936.

7.  Li Y., Zhong C. Q., Xu X., Cai S., Wu X., Chen J., Shi J., & Han J. (2015) Group-DIA, a software tool for analyzing multiple data-independent acquisition data files. Nat Methods 12(12):1105–6.

6.  Zhong C. Q., Li Y., Yang D., Zhang N., Xu X., Wu Y., Chen J., & Han J. (2014) Quantitative phosphoproteomic analysis of RIP3-dependent protein phosphorylation in the course of TNF-induced necroptosis. Proteomics 14(6):713-724.

5.  Wu T., Li Y., Huang D., Han F., Zhang Y. Y., Zhang D. W., & Han J. (2014) Regulator of G-protein signaling 19 (RGS19) and its partner Galpha-inhibiting activity polypeptide 3 (GNAI3) are required for zVAD-induced autophagy and cell death in L929 cells. PloS one 9(4):e94634.

4.  Wu X., He W. T., Tian S., Meng D., Li Y., Chen W., Li L., Tian L., Zhong C. Q., Han F., Chen J., & Han J. (2014) pelo is required for high efficiency viral replication. PLoS pathogens 10(4):e1004034.

3.  Wu X., Tian L., Li J., Zhang Y., Han V., Li Y., Xu X., Li H., Chen X., Chen J., Jin W., Xie Y., Han J., & Zhong C. Q. (2012) Investigation of receptor interacting protein (RIP3)-dependent protein phosphorylation by quantitative phosphoproteomics. Molecular & cellular proteomics 11(12):1640-1651.

2.  Li H., Ye C., Ji G., Wu X., Xiang Z., Li Y., Cao Y., Liu X., Douek D. C., Price D. A., & Han J. (2012) Recombinatorial biases and convergent recombination determine interindividual TCRbeta sharing in murine thymocytes. Journal of immunology 189(5):2404-2413.