Research Interests:

Development of new methods for unknown xenobiotics transformation products discovery

Characterization of the toxicity mechanism using global omics method (e.g., metabolomics and transcriptomics)

Identification of active compounds in complex mixtures using high-resolution mass spectrometry.

Research Experience:

1/2021-2/2023 Postdoctoral Fellow in Nanyang Environment & Water Research Institute (NEWRI), Nanyang Technological University, Singapore

8/2015-10/2020 Ph.D in Environmental Engineering, Nanyang Technological University, Singapore

7/2014-7/2015 MSc. in Environmental Engineering, Nanyang Technological University, Singapore

9/2010-7/2014 B.S. in Environmental Engineering (Major); Japanese Language (Minor) in Shanxi University, Taiyuan, China

Publications:

1. Min Liu, Shenglan Jia, Ting Dong, Qin Yang, Mingliang Fang^*. (2020) Metabolomic and transcriptomic analysis of MCF-7 cells exposed to 23 chemicals at human-relevant levels: estimation of individual chemical contribution to effects. Environmental Health Perspectives. 128 (12), 127008
2. Min Liu, Jie Jiang, Jie Zheng, Tao Huan, Bei Gao, Xunchang Fei, Yulan Wang, and Mingliang Fang^*. (2021). RTP: One Effective Platform to Probe Reactive Compound Transformation Products and Its Applications for a Reactive Plasticizer BADGE. Environmental Science & Technology. 55, 23, 16034–16043
3. Min Liu, Bo Peng, Guanyong Su, Mingliang Fang. (2021). Reactive Flame Retardants: Are They Safer Replacements? Environmental Science & Technology. 55, 21, 14477-14479
4. Yingdan Zhang^#, Min Liu^#*, Danyu Koh, Yujue Wang, Benedikt Warth, Da Chen, Mingliang Fang^*. Impact of Mixture Effects between Emerging Organic Contaminants on Cytotoxicity: A Systems-Biological Understanding of Synergism between TDCPP and TPP. Environmental Science & Technology. 54 (17), 10722-10734
5. Haoduo Zhao ^#, Min Liu ^#, Yunbo Lv, Mingliang Fang (2022). Dose-response metabolomics and pathway sensitivity to map molecular cartography of bisphenol A exposure. Environment International. 158, 106893
6. Liu, M., Jia, S., Dong, T., Han, Y., Xue, J., Wanjaya, E. R., & Fang, M.* (2019). The occurrence of bisphenol plasticizers in paired dust and urine samples and its association with oxidative stress. Chemosphere, 216, 472-478. doi: 10.1016/j.chemosphere.2018.10.090.
7. Dongqi Wang et al., Min Liu^*. (2021) A comprehensive review on the analytical method, occurrence, transformation and toxicity of a reactive pollutant: BADGE, Environment International. 155, 106701
8. Guang-Lei Ma, Hartono Candra, Li Mei Pang, Juan Xiong, Yichen Ding, Hoa Thi Tran, Zhen Jie Low, Hong Ye, Min Liu, Jie Zheng, Mingliang Fang, Bin Cao, Zhao-Xun Liang. (2022) Biosynthesis of Tasikamide via Path Biosynthesis of Tasikamides via Pathway Coupling and Diazonium-Mediated Hydrazone Formation. Journal of the American Chemical Society.144 (4): 1622-1633
9. Bo Peng, Min Liu, Yuan Han, Elvy Riani Wanjaya, Mingliang Fang*. (2019). Competitive Biotransformation among Phenolic Xenobiotic Mixtures: Underestimated Risks for Toxicity Assessment. Environmental Science & Technology, 53 (20), 12081-12090.
10. Shipei Xing, Yan Hu, Zixuan Yin, Min Liu, Xiaoyu Tang, Mingliang Fang, Tao Huan. (2020) Retrieving and utilizing hypothetical neutral losses from tandem mass spectra for spectral similarity analysis and unknown metabolite annotation. Analytical Chemistry 92 (21), 14476-14483
11. Yingdan Zhang, Tharushi Prabha Keerthisinghe, Yuan Han, Min Liu, Elvy Riani Wanjaya, Mingliang Fang*. (2018). “Cocktail” of xenobiotics at human relevant levels reshapes the gut bacterial metabolome in a species-specific manner. Environmental Science & Technology, 52 (19), 11402-11410. doi: 10.1021/acs.est.8b02629.
12. Shenglan Jia, Tengfei Xu, Tao Huan, Maria Chong, Min Liu, Wenjuan Fang, Mingliang Fang*. (2019). Chemical Isotope Labeling Exposome (CIL-EXPOSOME): one High-throughput Platform for Human Urinary Global Exposome Characterization. Environmental Science & Technology, 53 (9), 5445-5453. doi: 10.1021/acs.est.9b00285.
13. JJ Yang, Y Han, CH Mah, E Wanjaya, B Peng, TF Xu, M Liu, T Huan, ML Fang*. (2019). Streamlined MRM Method Transfer between Instruments Assisted with HRMS Matching and Retention-time Prediction. Analytica Chimica Acta, doi: 10.1016/j.aca.2019.12.002.
14. Shenglan Jia, Gayatri Sankaran, Bei Wang, Hongtao Shang, Sze Tat Tan, Hooi Ming Yap, Joanna Shen, Ramona Alikiiteaga Gutiérrez, Wenjuan Fang, Min Liu, Victor Wei-Chung Chang, Lee Ching Ng, Mingliang Fang*. (2019). Exposure and Risk Assessment of Volatile Organic Compounds and Airborne Phthalates in Singapore’s Child Care Centers, Chemosphere, 224, 85-92. doi: 10.1016/j.chemosphere.2019.02.120.
15. Haoduo Zhao, Min Liu, Junjie Yang, Yuyang Chen & Mingliang Fang et al. "Time-dependent metabolomics uncover dynamic metabolic adaptions in MCF-7 cells exposed to bisphenol A." Frontiers of Environmental Science & Engineering 17.1 (2023): 4. doi:
16. Haoduo Zhao, Caixia Li, Mihir Yogesh Naik, Jia Wu, Angelysia Cardilla, Min Liu, Fanrong Zhao, Shane Allen Snyder, Yun Xia, Guanyong Su, Mingliang Fang, et al. "Liquid Crystal Monomer: A Potential PPARγ Antagonist." Environmental Science & Technology 57, 9 (2023): 3758–3771. doi: 10.1021/acs.est.2c08109