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Recent publications

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2011
  1. Hirahatake KH, Meissen JK, Fiehn O, Adams SH (2011) Comparative Effects of Fructose and Glucose on Lipogenic Gene Expression and Intermediary Metabolism in HepG2 Liver Cells. PLoS ONE 6(11), e26583
  2. Brockmöller SF, Bucher E, Müller BM, Budczies J, Hilvo M, Griffin JL, Orešič M, Kallioniemi O, Iljin K, Loibl S, Darb-Esfahani S, Sinn BV, Klauschen F, Prinzler J, Bangemann N,  Ismaeel F, Fiehn O, Dietel M, Denkert C (2011) Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status and metabolic profiling J. Proteome Res.

  3. Kumari S, Stevens D, Kind T, Denkert C, Fiehn O (2011) Applying in-silico retention retention index and mass spectra matching for identification of unknown metabolites in accurate mass GC-TOF mass spectrometry. Analytical Chemistry 83, 5895-5902

  4. Skogerson K, Wohlgemuth G, Barupal DK, Fiehn O (2011) The volatile compound BinBase mass spectral database. BMC Bioinformatics 12: 321

  5. Fiehn O, Barupal DK, Kind T (2011) Extending biochemical databases by metabolomic surveys. J. Biol. Chem. 286, 23637-23643
  6. Wu D, Nishimura N, Kuo V, Fiehn O, Shahbaz S, Van Winkle L, F Matsumura F, Vogel CFA (2011) Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E−/− mice. Arteriosclerosis, thrombosis, and vascular biology 31, 1260-1267

  7. Ji Z, Hebbring S, Zhu H, Jenkins GC, Biernacka J, Snyder K, Drews M, Fiehn O, Zeng Z, Schaid D, Mrazek DA, Kaddurah-Daouk R, Weinshilboum RM (2011) Glycine and a glycine dehydrogenase SNP as Citalopram/Escitalopram response biomarkers in depression:  Pharmacometabolomics-informed pharmacogenomics. Clin. Pharm. Therap. 89, 97-104

  8. Hilvo M, Denkert C, Lehtinen L, Mueller B, Brockmoeller S, Seppaenen-Laakso T, Budczies J, Bucher E, Yetukuri L, Castillo S, Berg E, Nygren H, Sysi-Aho M, Griffin JL, Fiehn O, Loibl S, Richter-Ehrenstein C, Radke C, Hyoetylaeinen T, Kallioniemi O, Iljin K, Oresic M (2011) Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res. 71, 3236-3245

  9. Robertson D, Ruepp S, Stryker S, Hnatyshyn S, Shipkova P, Aranibar N, Mcnaney C, Fiehn O, Reily M (2011) Metabolomic and transcriptomic changes induced by overnight (16h) fasting in male and female Sprague-Dawley rats. Chem. Res. Toxicol. 24, 481-487

  10. Buckendahl AC, Budczies J, Fiehn O, Darb-Esfahani S, Kind T, Noske A, Weichert W, Sehouli J, Braicu E, Dietel M, Denkert C (2011) Prognostic impact of AMP-activated protein kinase expression in ovarian carcinoma: Correlation of protein expression and GC/TOF-MS based metabolomics. Oncol. Rep. 25, 1005-10012.

  11. Fiehn O, Kind T, Barupal DK (2011) Data processing, metabolomic databases and pathway analysis.  Annual Plant Reviews 43, 367-406

  12. Rellán-Álvarez R, El-Jendoubi H, Wohlgemuth G, Abadía A, Fiehn O, Abadía J, Álvarez-Fernández A. (2011) Metabolite profile changes in xylem sap and leaf extracts of Strategy I plants in response to iron deficiency and resupply. Frontiers Plant Nutr. (accepted)

    2010

  13. Wohlgemuth G, Haldiya P, Willighagen E, Kind T, Fiehn O (2010) The Chemical Translation Service (CTS) – a web-based tool to improve standardization of metabolomic reports. Bioinformatics 26, 2647-2648

  14. Fiehn O, Garvey T, Newman JW, Lok KH, Hoppel CL, Adams S (2010) Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PLoS ONE 5(12), e15234
  15. Zhang B, Tolstikov VV, Turnbull C, Hicks L, Fiehn O (2010) Divergent metabolome and proteome suggests functional independence of dual phloem transport systems in cucurbits.  Proc. Natl. Acad. Sci. USA 107, 13532-13537
  16. Luengwilai K, Fiehn O, Beckles D (2010) Comparison of leaf and fruit metabolism in two tomato (Solanum lycopersicum L.) genotypes varying in total soluble solids. J. Agric. Food Chem. 58, 11790-11800
  17. Kind T, Fiehn O (2010) Advances in structure elucidation of small molecules using mass spectrometry. Bioanal. Rev. 2, 23-60
  18. Brosnan RJ, Steffey EP, Escobar A, Palazoglu M, Fiehn O (2010) Anesthetic induction with guaifenesin and propofol in adult horses. Am J. Vet. Res. (accepted)
  19. Reichenbach SE, Tiana X, Tao Q, Ledford EB, Wuc Z, Fiehn O (2010) Informatics for cross-sample analysis with comprehensive two-dimensional gas chromatography and high-resolution mass spectrometry (GCxGC-HRMS). Talanta (accepted)
  20. Sana TR, Fischer S, Wohlgemuth G, Katrekar A, Jung K-H, Ronald PC, Fiehn O (2010) Metabolomics and transcriptomics analysis of the rice response to the bacterial blight pathogen Xanthomonas oryzae pv. oryzae. Metabolomics 6, 451-465
  21. Barupal DK, Kind T, Kothari SL, Lee DY, Fiehn O (2010) Hydrocarbon phenotyping of algal species using pyrolysis-gas chromatography mass spectrometry. BMC Biotechnology 10: 40
  22. Taylor SL, Ganti S, Bukanov NO, Chapman A, Fiehn O, Osier M, Kyoungmi K, Weiss RH (2010) A metabolomics approach using juvenile cystic mice to identify urinary biomarkers and altered pathways in polycystic kidney disease. AJP Renal Physiol. 298, F909-F922
  23. Abate S, Ahn YG, Kind T, Cataldi T, Fiehn O (2010) Determination of elemental compositions by gas chromatography - time of flight mass spectrometry using chemical and electron ionization. Rapid Comm. Mass Spectrom. 24, 1172-1180
  24. Rellan-Alvarez R, Andaluz S, Rodriguez-Celma J, Wohlgemuth G, Zocchi G, Alvarez-Fernandez A, Fiehn O, Lopez-Millan AF, Abadia J (2010) Changes in the proteomic and metabolic profiles of Beta vulgaris root tips in response to iron deficiency and resupply. BMC Plant Biol. 10: 120
  25. Skogerson K, Harrigan G, Reynolds T, Halls S, Ruebelt M, Iandolino A, Pandravada A, Glenn K, Fiehn O. (2010) The impact of genetics and environment on the metabolite composition of maize grain. J. Agric. Food Chem. 58, 3600-3610
  26. Bais P, Moon S, He K, Leito R, Dreher K, Walk T, Sucaet Y, Barkan L, Wohlgemuth G, Roth MR, Wurtele ES, Dixon P, Fiehn O, Lange BM, Shulaev V, Sumner LW, Welti R, Nikolau B, Rhee SY, Dickerson JA (2010) PlantMetabolomics.org: A web portal for Plant Metabolomics Experiments. Plant Physiol. 152, 1807-1816
  27. Seifert E, Fiehn O, Bezaire V, Bickel D, Wohlgemuth G, Adams S, Harper ME (2010) Long-chain fatty acid combustion rate is associated with unique metabolite profiles in skeletal muscle mitochondria. PLoS one 5,  e9834
  28. Shin MH, Lee DY, Wohlgemuth G, Choi IG, Fiehn O, Kim KH. (2010) Global metabolite profiling of agarose degradation by Saccharophagus degradans 2-40. New Biotechnol. 27, 156-168
  29. Shin MH, Lee DY, Liu KH, Fiehn O, Kim KH. (2010) Evaluation of sampling and extraction methodologies for the global metabolic profiling of Saccharophagus degradans. Anal. Chem. 82, 6660-6666


    2009 
  30. Kind T, Fiehn O. (2009) What are the obstacles for an integrated system for comprehensive interpretation of cross-platform metabolic profile data? Bioanalysis 1(9), 1511-1514.
  31. Kind T, Wohlgemuth G, Lee DY, Lu L, Palazoglu M, Shahbaz S, Fiehn O (2009) FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal. Chem. 81, 10038–10048
  32. Kind T, Leamy T, Leary J, Fiehn O (2009) Software platform virtualization in chemistry research and university teaching. J. Cheminformatics 1:18
  33. Kind T, Scholz M, Fiehn O (2009) How large is the metabolome? A critical analysis of data exchange practices in chemistry. PLoS one 4(5): e5440
  34. Hartman A, Lough DM, Barupal DK, Fiehn O, Fishbein T, Zasloff M, Eisen J (2009) Human gut microbiome adopts an alternative state following small bowel transplantation. Proc. Natl. Acad. Sci. USA 106, 17187-17192
  35. Skogerson K, Runnebaum R, Wohlgemuth G, de Ropp J, Heymann H, Fiehn O (2009) Comparison of GC-TOF MS and 1H-NMR metabolite identification in white wines from a sensory study investigating wine body. J. Agric. Food Chem. 57, 6899-6907
  36. Matsuda F, Shinbo Y, Oikawa A, Masami Y, Fiehn O, Kanaya S, Saito K (2009) Assessment of metabolome annotation quality: A method for evaluating the false discovery rate of elemental composition searches. PLoS one 4(10): e7490
  37. Burke G, Fiehn O, Moran N (2009) Effects of facultative symbionts and heat stress on the metabolome of pea aphids. ISME Journal 4, 242-252
  38. Shin MH, Lee DY, Skogerson K, Wohlgemuth G, Choi IG, Fiehn O, Kim KH. (2009) Global metabolic profiling of plant cell wall polysaccharide degradation by Saccharophagus degradans. Biotechnology and Bioengineering 105, 477-488
  39. Martinelli F, Uratsu SL, Reagan RL, Chen Y, Tricoli D, Fiehn O, Rocke DM, Gasser CS, Dandekar AM (2009) Gene regulation in parthenocarpic tomato fruit. J. Exp. Bot. 60, 3873-3890

  40. Dandekar AM, Martinelli F, Davis C, Bhushan A, Zhao W, Fiehn O, Skogerson K, Wohlgemuth G, D’Souza R, Roy S, Reagan RL, Lin D, Cary RB, Pardington P, Gupta G (2010) Analysis of early host responses for asymptomatic disease detection and management of specialty crops. Critical Reviews in Immunology 30, 277-289

  41. Scalbert A, Brennan L, Fiehn O, Hankemeier T, Kristal BS, van Ommen B, Pujos-Guillot E, Verhej E, Wishart D, Wopereis S (2009) Mass spectrometry based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research. Metabolomics 5, 435-458



     2008
  42. Denkert C, Budczies J, Weichert W, Wohlgemuth G, Scholz M, Kind T, Niesporek S, Noske A, Buckendahl A, Dietel M, Fiehn O (2008) Metabolic profiling of human colon carcinoma - Deregulation of TCA and amino acid turnover. Mol. Cancer 7: 72
  43. Taylor CF et al (2008) Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project. Nature Biotechnol. 26, 889-896
  44. Fiehn O, Wohlgemuth G, Scholz M, Kind T, Lee DY, Lu Y, Moon S, Nikolau BJ (2008) Quality control for plant metabolomics: Reporting MSI-compliant studies. Plant J. 53, 691-704
  45. Lee DY, Fiehn O (2008) High quality metabolomic data for Chlamydomonas reinhardtii. Plant Methods 4: 7
  46. Fiehn O (2008) Extending the breadth of metabolite profiling by gas chromatography/mass spectrometry. TrAC - Trends Anal. Chem. 27, 261-269
  47. Ikegami T, Horie K, Saad N, Hosoya N,  Fiehn O, Tanaka N (2008) Highly efficient analysis of underivatized carbohydrates using monolithic silica-based capillary hydrophilic interaction (HILIC) HPLC. Anal. Bioanal. Chem. 391, 2533-2542
  48. Lisec J, Meyer RC, Steinfath M, Redestig H, Becher M, Witucka-Wall H, Fiehn O, Torjek O, Selbig J, Altmann T, Willmitzer L. (2008) Identification of metabolic and biomass QTL in Arabidopsis thaliana in a parallel analysis of RIL and IL populations. Plant J. 53, 960-972

  49. Ulu A, Davis BB, Tsai HJ, Kim IH, Morisseau C, Inceoglu B, Fiehn O, Hammock BD, Weiss RH. (2008) Soluble epoxide hydrolase inhibitors reduce the development of atherosclerosis in apolipoprotein e-knockout mouse model. J Cardiovasc Pharmacol. 52,314-23.

      

    2007
  50. Kose F, Budczies J, Holschneider M, Fiehn O (2007) Robust detection and verification of linear relationships to generate metabolic networks using estimates of technical errors. BMC Bioinformatics 8:162

  51. Kind T, Fiehn O (2007) Seven golden rules for heuristic filtering of molecular formulas obtained by accurate mass spectrometry. BMC Bioinformatics 8: 115  (supporting information and freeware)

  52. Horie K, Kimura H, Ikegami T, Iwatsuka A, Saad N, Fiehn O, Tanaka N (2007) Calculating optimal modulation periods to maximize the peak capacity in two-dimensional HPLC. Anal. Chem. 79, 3764-3770

  53. Huster D, Purnat TD, Burkhead JL, Ralle M, Fiehn O, Stuckert F, Olson NE, Teupser D, Lutsenko S (2007) Higher copper selectivity alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease. J. Biol. Chem. 282, 8343-8355
  54. Horie K, Ikegami T, Hosoya K, Saad N, Fiehn O, Tanaka N (2007) Highly efficient monolithic silica capillary columns modified with poly(acrylic acid) for hydrophilic interaction chromatography. J. Chromatogr. A 1164, 198-205

  55. Fiehn O, Robertson D, Griffin J, van der Werf M, Nikolau B, Morrison N, Sumner LW, Goodacre R, Hardy NW, Taylor C, Fostel J, Kristal B, Kaddurah-Daouk R, Mendes P, van Ommen B, Lindon JC, Sansone S-A (2007) The Metabolomics Standards Initiative (MSI). Metabolomics 3, 175-178

  56. Fiehn O, Sumner LW, Rhee SY, Ward J, Dickerson J, Lange BM, Lane G, Roessner U, Last R, Nikolau B (2007) Minimum reporting standards for plant biology context information in metabolomic studies. Metabolomics 3, 195-201

  57. Sumner LW, Amberg A, Barrett D, Beger R, Beale MH, Daykin C, Fan TWM, Fiehn O, Goodacre R, Griffin JL, Hankemeier T, Hardy N, Higashi R, Kopka J, Lindon JC, Lane AN, Marriott P, Nicholls AW, Reilly MD, Viant M (2007) Proposed minimum reporting standards for chemical analysis. Metabolomics 3, 211-221
  58. Sansone S-A, Nikolau B, van Ommen B, Taylor C, Robertson D, Lindon J, Griffin JL, Sumner LW, van der Werf M, Hardy NW, Morrison N, Mendes P, Kaddurah-Daouk R, Goodacre R, Fan T, Fiehn O (2007) The Metabolomics Standards Initiative. Nature Biotechnol. 25, 846-848

  59. Meyer RC, Steinfath M, Lisec J, Becher M, Witucka-Wall H, Toerjek O, Fiehn O, Eckardt A, Willmitzer L,  Selbig J, Altmann T (2007) The metabolic signature related to high plant growth rate in Arabidopsis thaliana. Proc. Natl. Acad. Sci. USA 104, 4759-4764

  60. Scholz M, Fiehn O (2007) SetupX - A Public Study Design Database for Metabolomic Projects. Pacific Symp. Biocomp. 12, 169-180

  61. Frey I, Rubio-Aliaga I, Siewert A, Sailer D, Drobyshev A, Beckers J, Aubert J, Bar Hen A, Fiehn O, Eichinger H, Daniel H (2007) Profiling at mRNA, protein and metabolite level reveals alterations in renal amino acid handling and glutathione metabolism in kidney tissue of Pept2-/- mice. Physiol. Genomics 28, 301-310

  62. Kind T, Tolstikov VV, Fiehn O, Weiss RH (2007) A comprehensive urinary metabolomics approach for identifying kidney cancer. Anal. Biochem. 363, 185-195
  63. Fiehn O (2007) Cellular Metabolomics: The Quest for Pathway Structure. In: The Handbook of Metabonomics and Metabolomics, Chapter 2. Eds. Lindon JC, Nicholson JK, Holmes E. Elsevier BV, Amsterdam and Oxford, ISBN-13: 978-0-44-452841-4, pp. 35-54
  64. Dixon RA, Gang DR, Charlton AJ, Fiehn O, Kuiper HA, Reynolds TL, Tjeerdema RS, Jeffery EH, German JB, Ridley WP, Seiber JN (2007) Applications of Metabolomics in Agriculture. J. Agr. Food Sci. 54, 8984-8994
  65. Fiehn, O (2007) Validated high quality automated metabolome analysis of Arabidopsis thaliana leaf disks. In: Concepts in Plant Metabolomics. Chapter 1. Eds. Nikolau BJ, Wurtele ES. Springer, New York, 1-18

    2006
  66. Denkert C, Budczies J, Kind T, Weichert W, Tablack P, Sehouli J, Niesporek S, Koensgen D, Dietel M, Fiehn O (2006) GC-TOF based metabolic profiling reveals different metabolite patterns in invasive ovarian carcinomas and ovarian borderline tumors. Cancer Res. 66, 10795-10804
  67. Fiehn O (2006) Study of metabolic control in plants by metabolomics. In: Control of Primary Metabolism in Plants. Eds. Plaxton WC and McManus MT. Blackwell, Annual Plant Reviews 22, 60-84
  68. Kind T, Fiehn O (2006) Metabolomic database annotations via query of elemental compositions: Mass accuracy is insufficient even at less than 1 ppm. BMC Bioinformatics 7:234; see supplemental material 

  69. Fiehn O, Kristal B, v Ommen B, Sumner LW, Sansone SA, Taylor C, Hardy N, Kaddurah-Daouk R (2006) Establishing Reporting Standards for Metabolomic and Metabonomic Studies: A Call for Participation. OMICS 10, 158-163

  70. Perroud B, Lee J, Valkova N, Dhirapong A, Lin P-Y, Fiehn O, Kueltz D, Weiss RH (2006) Pathway analysis of kidney cancer using proteomics and metabolic profiling. BMC Mol. Cancer 5:64
  71. Fiehn O, Kind T (2006) Metabolite profiling in blood plasma. In: Metabolomics: Methods and Protocols. Weckwerth W (ed.), Humana Press, Totowa NJ, ISBN13: 978-1-59745-244-1. Methods in Molecular Biology 358, 3-18
  72. Fiehn O, Weckwerth W (2006) Mass spectrometry: Quantitation. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Ganten D, Ruckpaul K (eds.), Springer, New York/Heidelberg, ISBN: 3-540-44244-8, DOI 10.1007/3-540-29623-9_3550, part 13, 1030-1034
  73. Fiehn O (2006) Metabolite Profiling in Arabidopsis. In: Arabidopsis Protocols 2nd edition. Salinas J, Sanchez-Serrano JJ (eds.), Methods in Molecular Biology ser., Humana Press, Totowa NJ, 439-447

  74. Hannah MA, Wiese D, Freund S, Fiehn O, Heyer AG, Hincha DK (2006) Natural Genetic Variation of Freezing Tolerance in Arabidopsis   Plant Physiol. 142, 98-112

  75. Castle LA, Fiehn O, Kaddurah-Daouk R, Lindon JC (2006) Metabolomics standards workshop and the development of international standards for reporting metabolomics experimental results. Brief. Bioinformatics 7, 159-165

    2005
  76. Fiehn O, Wohlgemuth G, Scholz M (2005) Setup and Annotation of Metabolomic Experiments by Integrating Biological and Mass Spectrometric Metadata. Proc. Lect. Notes Bioinformatics 3615, 224-239 
  77. Boelling C, Fiehn O (2005) Metabolite profiling of Chlamydomonas reinhardtii under nutrient deprivation. Plant Physiol. 139, 1995-2005
  78. Catchpole G, Beckmann M, Enot DP, Mondhe M, Zywicki B, Taylor J, Hardy N, Smith A, King RD, Kell DB, Fiehn O, Draper J. (2005) Phenotyping by hierarchical metabolomics to assess similarity of genetically modified and conventional crops. Proc. Natl. Acad. Sci.  USA  102, 14458-14462
  79. Schad M., Mungur R., Fiehn O., Kehr J. (2005) Metabolic profiling of laser microdissected vascular bundles of Arabidopsis thaliana. Plant Methods 1:2
  80. Shellie RA, Welthagen W, Zrostlikova J, Spranger J, Ristow M, Fiehn O, Zimmermann R (2005) Statistical methods for comparing GC x GC-TOFMS chromatograms: metabolomic analysis of mouse tissue extracts. J. Chromatogr. A 1086,83-90 
  81. Nikiforova VJ, Kopka J, Tolstikov V, Fiehn O, L Hopkin L, Hawkesford MJ, Hesse H, Hoefgen R. (2005) Systems rebalancing of metabolism in response to sulfur deprivation, as revealed by metabolome analysis of Arabidopsis plants. Plant Physiol. 138, 304-318
  82. Welthagen W, Shellie R, Ristow M, Spranger J, Zimmermann R, Fiehn O (2005) Comprehensive two dimensional gas chromatography – time of flight mass spectrometry, GCxGC-TOF for high resolution metabolomics: Biomarker discovery on spleen tissue extracts of obese NZO compared to lean C57BL/6 mice. Metabolomics 1, 57-65 
  83. Zywicki B, Catchpole G, Draper J, Fiehn O (2005) Comparison of rapid liquid chromatography-electrospray ionization-tandem mass spectrometry methods for determination of glycoalkaloids in transgenic field-grown potatoes. Anal. Biochem. 336, 178-186

    2004
  84. Cook D, Fowler S, Fiehn O, Tomashow M (2004) Role of the CBF cold response pathway in configuring the low temperature metabolome of Arabidopsis. Proc. Natl. Acad Sci. USA 101, 15243-15248 
  85. Weckwerth W, Loureiro ME, Wenzel K, Fiehn O (2004) Metabolic networks unravel the effects of silent plant phenotypes. Proc. Natl. Acad. Sci. USA 101, 7809-7814
  86. Jenkins H, Hardy N, Beckmann M, Draper J, Smith AR, Taylor J, Fiehn O, Goodacre R, Bino R, Hall R, Kopka J, Lane GA, Lange BM, Liu JR, Mendes P, Nikolau BG, Oliver SG, Paton NW, Rhee S, Roessner-Tunali U, Saito K, Smedsgard J, Sumner LW, Wang T, Walsh S, Wurtele ES, Kell DB (2004) A proposed framework for the description of plant metabolomics experiments and their results. Nat. Biotechnol. 22, 1601-1605 
  87. Bino RJ, Hall RD, Fiehn O, Kopka J, Saito K, Draper J, Nikolau B, Mendes P, Roessner-Tunali U, Beale M, Trethewey RN, Lange BM, Wurtele ES, Sumner LW (2004) Potential of metabolomics as a functional genomics tool. Trends Plant Sci. 9, 418-425
  88. Wienkoop S, Glinski M, Tanaka N, Tolstikov VV, Fiehn O, Weckwerth W (2004) Linking protein fractionation with multidimensional monolithic reversed-phase peptide chromatography/mass spectrometry enhances protein identification from complex mixtures even in the presence of abundant proteins. Rapid Commun. Mass Spectrom. 18, 643–650
  89. Weckwerth W, Wenzel K, Fiehn O (2004) Process for the integrated extraction, identification and quantification of metabolites, proteins and RNA to reveal their co-regulation in biochemical networks. Proteomics 4, 78-83 
  90. Scholz M, Gatzek S, Sterling A., Fiehn O, Selbig J (2004) Metabolite fingerprinting: detecting biological features by independent component analysis. Bioinformatics 20, 2447 - 2454

    2003
  91. Tolstikov VV, Lommen A, Nakanishi K, Tanaka N, Fiehn O (2003) Monolithic silica-based capillary reversed-phase liquid chromatography/electrospray mass spectrometry for plant metabolomics. Anal. Chem. 75, 6737-6740 
  92. Fiehn O (2003) Metabolic networks of Cucurbita maxima phloem. Phytochemistry 62, 875-886 
  93. Fiehn O, Spranger J (2003) Can metabolomics be used for assessing nutritional dependent human diseases? Phytochem. Rev. 1, 223-230 
  94. Fiehn O, Spranger J (2003) Use of metabolomics to discover metabolic patterns associated with human diseases. In: Metabolic Profiling. Its role in biomarker discovery and gene function analysis. Harrigan GG, Godacre R. Kluwer Academic Publishers, Boston/Dordrecht/London. Chapter 11 pp 199-215 
  95. Steuer R, Kurths J, Fiehn O, Weckwerth W (2003) Interpreting correlations in metabolomic networks. Biochem. Soc. Trans. 31, 1476-1478
  96. Steuer R, Kurth J, Fiehn O, Weckwerth W (2003) Observing and interpreting correlations in metabolic networks. Bioinformatics 19, 1019-1026 
  97. Weckwerth W, Fiehn O (2003) Deciphering metabolic networks Eur. J. Biochem (270, 579-588

    2002 
  98. Taylor J, King RD, Altmann T, Fiehn O (2002) Application of metabolomics to plant genotype discrimination using statistics and machine learning. Bioinformatics 18, S241-S248 Suppl. S 
  99. Fiehn O, Weckwerth W (2002) Can we discover novel pathways using metabolomic analysis? Curr. Opin. Biotechnol. 13, 156-160 
  100. Tolstikov VV, Fiehn O (2002) Analysis of highly polar compounds of plant origin: combination of hydrophilic interaction chromatography and electrospray ion trap mass spectrometry. Anal Biochem 301, 298-307

    2001
  101. Kose F, Weckwerth W, Linke T, Fiehn O (2001) Visualizing plant metabolomic correlation networks using clique-metabolite matrices. Bioinformatics 17, 1198-1208 
  102. Fiehn O (2002) Metabolomics – the link between genotype and phenotype. Plant Mol. Biol. 48, 155-171 
  103. Vogel G, Fiehn O, Jean-Richard-dit-Bressel L, Boller T, Wiemken A, Aeschbacher RA, Wingler A (2001) Trehalose metabolism in Arabidopsis: occurrence of trehalose and molecular cloning and characterization of trehalose-6-phosphate synthase homologues. J. Exp. Bot. 52,, 1817-1826 
  104. Fiehn O (2001) Combining genomics, metabolome analysis, and biochemical modelling to understand metabolic networks. Comp. Funct. Genom. 2, 155-168 
  105. Fiehn O, Kloska S, Altmann T (2001) Integrated studies on plant biology using multi parallel techniques. Curr. Opin. Biotechnol. 12, 82-86 
  106. Roessner U, Luedemann A, Brust D, Fiehn O, Linke T, Willmitzer L, Fernie AR (2001) Metabolic profiling allows comprehensive phenotyping of genetically or environmentally modified plant systems. Plant Cell 13, 11-29

    2000
  107. Fiehn O, Kopka J, Dörmann P, Altmann T, Trethewey RN, Willmitzer L (2000) Metabolite profiling for plant functional genomics. Nat. Biotechnol. 18, 1157-1161 
  108. Weckwerth W, Willmitzer L, Fiehn O (2000) Comparative quantification and identification of phosphoproteins using stable isotope labeling and liquid chromatography/mass spectrometry. Rapid Comm. Mass Spectrom. 14, 1677-1681 
  109. Fiehn O, Kopka J, Trethewey RN, Willmitzer L (2000) Identification of uncommon plant metabolites based on calculation of elemental compositions using gas chromatography and quadrupole mass spectrometry. Anal. Chem. 72, 3573-3580 
  110. Goodlett DR, Bruce JE, Anderson GA, Rist B, Pasa-Tolic L, Fiehn O, Smith RD, Aebersold R (2000) Protein identification with a single accurate mass of a cysteine-containing peptide and constrained database searching. Anal. Chem. 72, 1112-1118

    1999 and earlier
  111. Reemtsma T, Fiehn O, Jekel M (1999) A modified method for the analysis of organics in industrial waste water as directed by their toxicity to Vibrio fischeri. Fresen. J. Anal. Chem. 363, 771-776 
  112. Fiehn O, Wegener G, Jochimsen J, Jekel M (1998) Analysis of the ozonation of 2-mercaptobenzothiazole in water and tannery waste water using sum parameters, liquid and gas chromatography, and capillary electrophoresis. Wat. Res. 32, 1075-1084 
  113. Fiehn O, Wegener G, Jekel M (1998) Capillary electrophoretic analysis of organic anions in tannery waste water including high contents of chloride and sulfate. Intern. J. Environ. Anal. Chem. 69, 257-271 
  114. Fiehn O, Vigelahn L, Kalnowski G, Reemtsma T, Jekel M (1997) Toxicity directed fractionation of tannery waste water using solid-phase extraction and luminescence inhibition in microtiter plates. Acta Hydrochim. Hydrobiol. 254, 1-6 
  115. Fiehn O, Jekel M (1997) Analysis of phenolic compounds in industrial waste water with HPLC and post-column reaction detection. J. Chromatogr. 769, 189-200 
  116. Fiehn O, Jekel M (1996) Comparison of sorbents using semipolar to highly hydrophilic compounds for a sequential solid-phase extraction procedure of industrial waste waters. Anal. Chem. 68, 3083-3089 
  117. Reemtsma T, Fiehn O, Kalnowski G, Jekel M (1995) Microbial transformations and biological effects of fungicide-derived benzothiazoles determined in industrial waste water. Environ. Sci. Technol. 29, 478-485 
  118. Fiehn O, Reemtsma T, Jekel M (1994) Extraction and analysis of various benzothiazoles from industrial wastewater. Anal. Chim. Acta 295, 297-305 
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Last modified 2011-11-18 11:15 AM
 
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