The Core Lab
UC Davis
Metabolomics 2008 4th Annual Conference, Sept. 2-6, 2008
new Team members: Saeed Khazaie
Section of Molecular and Cellular Biology
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Examples could be the use of algae (Chlamydomonas) for analyzing metabolic networks in time series of stress conditions, or source-sink alterations upon pathogen infections. In order to analyze biochemicals we use cutting edge tools of analytical chemistry.
We aim at identification and quantification of all metabolites in a given biological situation, called metabolomics, for which we develop methods using mass spectrometry coupled to gas and liquid chromatography (GC/MS and LC/MS). The readout of this data is then structured and analyzed by multivariate statistics. As part of these efforts we have developed new distance metrics that robustly recognize co-regulation of pairs of metabolites which can then be visualized and compared by network graphs.
Ultimately we want to relate changes in these networks back to interactions with the underlying biochemical pathways, protein-protein interactions and genetic networks and in order to understand the relationship between the different cellular components in eukaryote cells.
Prof. Dr. Oliver Fiehn
Last modified 2005-05-23 10:31 AM
